https://aiscience.uk/tags/open-source/ Recent content in Open-Source on AI Science Report Hugo en-us Sun, 28 Jun 2026 00:00:00 +0800 https://aiscience.uk/posts/pvactools-v6-personalized-cancer-vaccines/ Sun, 28 Jun 2026 00:00:00 +0800 https://aiscience.uk/posts/pvactools-v6-personalized-cancer-vaccines/ <p>In June 2026, a 62-year-old melanoma patient who had already failed two lines of therapy received an experimental vaccine. It wasn&rsquo;t an off-the-shelf drug. It was built from the DNA of their own tumor, encoding 34 custom neoantigens selected by an algorithm trained on thousands of other patients&rsquo; cancers. Six months later, scans showed no new lesions.</p> <p>That vaccine, Moderna&rsquo;s mRNA-4157 (now called V940), is the most visible example of a quiet revolution in the open-source code repositories where computational biologists build the tools that make personalized cancer immunotherapy possible. One of those tools, pVACtools, just got its biggest update yet.</p>